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ReproFiv, year by year

Everything the Spanish National Activity Registry publishes about ReproFiv between 2012 and 2022: 10 years with data. Each year carries its own attribution, because each year is a separate publication of the registry.

Volume first

Activity comes before results on purpose: a high percentage over few cycles does not mean what the same percentage over many cycles means. The registry publishes cycles as bands and that is how we show them, never reduced to a single figure; transfers are an exact count.

Transfers recorded per year — IVF/ICSI with own oocytes
’12’13’14’15166’16’17’18’19’20’21’22
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Transfers recorded per year — IVF/ICSI with own oocytes
YearValue
201264
2014128
2015123
2016166
2017162
2018109
201978
202059
202152
202239
Transfers recorded per year — Egg donation
’12’13’1486’15’16’17’18’19’20’21’22
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Transfers recorded per year — Egg donation
YearValue
201239
201435
201586
201669
201749
201852
201950
202042
202143
202219

Results, year by year

Each band is the interval the registry published that year: the floor and the ceiling of the estimate, not a point. There is no line joining the years, and that is deliberate — joining the centres of successive intervals would assert a trend the data does not support.

IVF/ICSI with own oocytes · Under 35
  • Fresh embryos
  • Frozen embryos
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IVF/ICSI with own oocytes · Under 35
YearFresh embryosFrozen embryos
201225.1 – 84%40.2 – 91.7%
2014—7.9 – 64.8%
201513.2 – 53.5%35.7 – 80.1%
201641.5 – 84.8%27.9 – 57.8%
201731.2 – 83.1%70 – 96.7%
20181 – 99%35.5 – 71.2%
201920.5 – 93.8%26.6 – 60.9%
2020—27.6 – 62.7%
2021100 – 100%36.5 – 75.5%
20220 – 86.7%17.3 – 58.9%
IVF/ICSI with own oocytes · Between 35 and 39
  • Fresh embryos
  • Frozen embryos
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IVF/ICSI with own oocytes · Between 35 and 39
YearFresh embryosFrozen embryos
201211.6 – 49.2%35.6 – 73.8%
2014—38.5 – 81.5%
201520 – 52.8%40.9 – 80.8%
201613.1 – 45%34.9 – 65.1%
201712.4 – 51.3%30.1 – 56.7%
20180 – 55.1%20.3 – 44.1%
2019100 – 100%23.8 – 76.2%
2020100 – 100%32.4 – 71.6%
2021—17.2 – 54.8%
2022—0.5 – 49.5%
IVF/ICSI with own oocytes · Over 40
  • Fresh embryos
  • Frozen embryos
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IVF/ICSI with own oocytes · Over 40
YearFresh embryosFrozen embryos
20120.5 – 49.5%0 – 42.9%
2014—15.4 – 84.6%
20153.8 – 46.2%9.6 – 70.4%
20169.4 – 42.5%0 – 82.9%
20170 – 44.8%9.6 – 38.9%
2018—0 – 41%
Egg donation · Under 35
  • Fresh embryos
  • Frozen embryos
0255075100'12'13'14'15'16'17'18'19'20'21'22
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Egg donation · Under 35
YearFresh embryosFrozen embryos
2012100 – 100%100 – 100%
2014—32.6 – 100%
2015100 – 100%100 – 100%
201613.3 – 100%—
20171 – 99%—
2018100 – 100%13.3 – 100%
2019100 – 100%—
2021—100 – 100%
Egg donation · Between 35 and 39
  • Fresh embryos
  • Frozen embryos
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Egg donation · Between 35 and 39
YearFresh embryosFrozen embryos
201238.6 – 83.6%50.7 – 92.4%
201459 – 100%—
201553.8 – 96.2%12 – 64.9%
201635.2 – 92.1%—
20170 – 100%4 – 71%
201832.6 – 100%35.9 – 97.5%
201917.1 – 100%2.5 – 64.1%
20200 – 86.7%1 – 53.6%
2021100 – 100%0 – 62%
2022—100 – 100%
Egg donation · Over 40
  • Fresh embryos
  • Frozen embryos
0255075100'12'13'14'15'16'17'18'19'20'21'22
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Egg donation · Over 40
YearFresh embryosFrozen embryos
20120 – 82.9%9.6 – 97.1%
201425.1 – 84%0 – 82.9%
201540.7 – 75.4%32.6 – 78.5%
201633.2 – 76.8%—
20176.2 – 79.5%12.4 – 51.3%
201812 – 64.9%31 – 73.7%
201928.9 – 100%0 – 37.9%
20200 – 82.9%33.2 – 76.8%
2021100 – 100%26.7 – 62.9%
20220 – 100%4.3 – 49%
AIH — artificial insemination (partner’s sperm) · Under 40
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AIH — artificial insemination (partner’s sperm) · Under 40
YearUnder 40
20120 – 20.6%
20140 – 32.6%
AIH — artificial insemination (partner’s sperm) · Under 35
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AIH — artificial insemination (partner’s sperm) · Under 35
YearUnder 35
20150 – 26.1%
AIH — artificial insemination (partner’s sperm) · Between 35 and 39
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AIH — artificial insemination (partner’s sperm) · Between 35 and 39
YearBetween 35 and 39
20160 – 40.2%
20170 – 35.4%
2018100 – 100%
AID — artificial insemination (donor sperm) · Under 40
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AID — artificial insemination (donor sperm) · Under 40
YearUnder 40
20120 – 100%
20140 – 35.4%
AID — artificial insemination (donor sperm) · Under 35
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AID — artificial insemination (donor sperm) · Under 35
YearUnder 35
20150 – 55.1%
20180 – 67.4%
AID — artificial insemination (donor sperm) · Between 35 and 39
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AID — artificial insemination (donor sperm) · Between 35 and 39
YearBetween 35 and 39
20161 – 99%
20171 – 99%
20180 – 86.7%

Year-by-year table

The table is the exact and complete reading: everything in the charts, and more. Each row cites the wording the registry requires for that year.

YearName in the registryCycles startedTransfersPregnancy per transfer (under 35)Pregnancy per cycle (insemination)Attribution
2012ReproFivNo data10325.1 – 84%0 – 20.6%Registro Nacional de Actividad 2012-Registro SEF
2013No data
2014ReproFivNo data163No data0 – 32.6%Registro Nacional de Actividad 2014-Registro SEF
2015ReproFiv100-50020913.2 – 53.5%0 – 26.1%Registro Nacional de Actividad 2015-Registro SEF
2016ReproFiv100-50023541.5 – 84.8%0 – 40.2%Registro Nacional de Actividad 2016-Registro SEF
2017ReproFiv100-50021131.2 – 83.1%0 – 35.4%Registro Nacional de Actividad 2017-Registro SEF
2018ReproFiv100-5001611 – 99%100 – 100%Registro Nacional de Actividad 2018-Registro SEF
2019ReproFivNo data12820.5 – 93.8%No dataRegistro Nacional de Actividad 2019-Registro SEF
2020ReproFiv100-500101No dataNo dataRegistro Nacional de Actividad 2020-Registro SEF
2021ReproFivNo data95100 – 100%No dataRegistro Nacional de Actividad 2021-Registro SEF
2022ReproFivNo data580 – 86.7%No dataRegistro Nacional de Actividad 2022-Registro SEF

Gaps in the series, and how to read them

The registry’s province-by-province census returns empty for 2009 and 2010, even though the individual profiles for those years do exist and have been recovered one by one. A centre missing from a given year means the registry publishes no profile for it that year — not that it closed.

The registry’s template changed schema in 2014 and again in 2015: up to 2013, cycles, implantation and transfers are published without separating fresh from frozen embryos, and insemination is published for a single age band (“under 40”). That is why some years carry fewer series than others: it is what the source published, not a missing figure.

And most important: a change from one year to the next is not, on its own, an improvement or a decline. The patient mix changes, selection criteria change and, at small volumes, chance changes too. Wide intervals are precisely the signal that the exact number cannot be trusted.

Official guide: how to interpret a centre’s data (PDF, in Spanish)

← Back to the ReproFiv profile

Source: “Registro Nacional de Actividad 2022-Registro SEF” (Spanish National ART Activity Registry) — registrosef.com, retrieved 31 July 2026.